CDK4-IN-3
CDK4-IN-3 (Compound 389) is a potent irreversible cyclin-dependent kinase 4 (CDK4) inhibitor (IC50=25 nM, >10-fold selective over CDK6) . CDK4-IN-3 arrests the cell cycle at G₁ phase, and induces tumor cell apoptosis. CDK4-IN-3 is promising for research of solid tumors such as breast and lung cancers[1].
Product Specifications
CAS Number
[3002399-75-6]
UNSPSC
12352005
Target
Apoptosis; CDK
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
98.07
Solubility
DMSO : 8.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC(N1C2=CC(C3=NC(N[C@H]4[C@@H](COCC4)O)=NC=C3F)=CC=C2C(C(C)=C1C5CCCN5)=O)C
Molecular Formula
C26H32FN5O3
Molecular Weight
481.56
References & Citations
[1]Jing Li, et al. Substituted 7- (pyrimidin-4-yl) quinolin-4 (1h) -one compounds as cyclin dependent kinase inhibitors. WO2023208172A1. 2023-11-02.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK4; CDK6
Available Sizes
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