CR-3294
CR-3294 is an autophagy inducer in hypoxic cells. CR-3294 is an inducible enzyme nitric oxide synthase (iNOS) inhibitor. CR-3294 inhibits both the DNA binding of HIF-1alpha and VEGF mRNA synthesis. CR-3294 can be used for the study of breast cancer and inflammatory bowel disease (IBD), such as Crohn’s disease, ulcerative colitis[1].
Product Specifications
CAS Number
[457939-22-9]
UNSPSC
12352005
Target
Autophagy; NO Synthase
Related Pathways
Autophagy; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Smiles
CC(NC1=CC=C(NC(NCCCCC)=S)C=C1)=N
Molecular Formula
C14H22N4S
Molecular Weight
278.42
References & Citations
[1]Tafani M, et al. Induction of autophagic cell death by a novel molecule is increased by hypoxia. Autophagy. 2008 Nov;4 (8) :1042-53.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
INOS
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