C3001a
C3001a is a selective TREK-1 and TREK-2 channel activator with EC50 values of 12.81 μM and 11.31 μM, respectively. C3001a does not affect other two-pore domain K+ (K2P) channels. C3001a binds to the cryptic binding site formed by P1 and TM4 in TREK-1. C3001a can be used for the study of pain and pancreatitis[1].
Product Specifications
CAS Number
[2415154-29-7]
UNSPSC
12352005
Target
Potassium Channel
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Neurological Disease; Inflammation/Immunology
Smiles
O=C([C@@H]1C[C@H](C(NC2=CC=C(C3=NC4=CC=C(C)C=C4S3)C=C2)=O)CC1)O
Molecular Formula
C21H20N2O3S
Molecular Weight
380.46
References & Citations
[1]Qiu Y, et al. TREK Channel Family Activator with a Well-Defined Structure-Activation Relationship for Pain and Neurogenic Inflammation. J Med Chem. 2020 Apr 9;63 (7) :3665-3677.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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