Adrogolide

Adrogolide is an A-86929 (HY-171472) prodrug and dopamine D1 receptor agonist. Adrogolide is converted rapidly in plasma to A-86929. Adrogolide improves behavioral disability and locomotor activity scores. Adrogolide can also attenuate the ability of Cocaine to induce Cocaine-seeking behavior. Adrogolide can be used in the research of Parkinson's disease[1].

Product Specifications

CAS Number

[171752-56-0]

Product Name Alternative

ABT-431; DAS-431

UNSPSC

12352005

Target

Dopamine Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

CC(OC1=C(OC(C)=O)C=C2CC[C@@]3([H])NCC(SC(CCC)=C4)=C4[C@]3([H])C2=C1)=O

Molecular Formula

C22H25NO4S

Molecular Weight

399.50

References & Citations

[1]Giardina WJ, et al. Adrogolide HCl (ABT-431; DAS-431), a prodrug of the dopamine D1 receptor agonist, A-86929: preclinical pharmacology and clinical data. CNS Drug Rev. 2001 Fall;7 (3) :305-16.