SG3376
SG3376 is an antibody-drug conjugate (ADC) targeting human epidermal growth factor receptor 2 (HER2) . SG3376 is promising for research of HER2-overexpressing cancers (e.g., breast, gastric cancer) [1].
Product Specifications
CAS Number
[2139261-06-4]
UNSPSC
12352005
Target
Drug-Linker Conjugates for ADC; EGFR
Related Pathways
Antibody-drug Conjugate/ADC Related; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C1C2=CC(OC)=C(OCC3=CC(COC4=C(C=C5C(N=C[C@@]6([H])N(C=C(C6)C)C5=O)=C4)OC)=CC(C#CCNC(CCOCCOCCOCCOCCNC(CCN7C(C=CC7=O)=O)=O)=O)=C3)C=C2N=C[C@@]8([H])N1C=C(C8)C
Molecular Formula
C57H63N7O14
Molecular Weight
1070.15
References & Citations
[1]Tiberghien A C, et al. An optimised synthesis of SG3376, a non-cleavable antibody-drug conjugate pyrrolobenzodiazepine drug-linker[J]. Tetrahedron Letters, 2017, 58 (46) : 4363-4366.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6135733-01 0.1 mL
CD178 (Apoptosis Antigen Ligand, APT1LG1, APTL, CD95 Ligand, CD95L, CD95-L, FAS Antigen Ligand, Fas Ligand, FASL, FASLG, Tumor Necrosis Factor Ligand Superfamily Member 6, TNFSF6) APC
Ask
View Details MBS6135733-02 5x 0.1 mL
CD178 (Apoptosis Antigen Ligand, APT1LG1, APTL, CD95 Ligand, CD95L, CD95-L, FAS Antigen Ligand, Fas Ligand, FASL, FASLG, Tumor Necrosis Factor Ligand Superfamily Member 6, TNFSF6) APC
Ask
View Details