GDC-2992
GDC-2992 (Compound 28A) is an orally bioavailable androgen receptor (AR) PROTAC degrader. GDC-2992 degrads AR with a DC50 value of 2.7 nM and inhibits proliferation with an IC50 valude of 9.7 nM in VCaPcells. GDC-2992 can be used for prostatic cancer study. (Structure Note: Pink: target protein ligand (HY-130845) ; Blue: E3 ligase ligand (HY-W1003189A) ; Black: linker (HY-169975) ; E3 ligase ligand +linker (HY-169976A) ) [1].
Product Specifications
CAS Number
[2753651-10-2]
Product Name Alternative
RO7656594
UNSPSC
12352005
Target
Androgen Receptor; PROTACs
Related Pathways
PROTAC; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.38
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
N#CC1=CC=C(O[C@H]2C(C)(C)[C@H](NC(C3=CC=C(N4CCC(CN5CCN(C6=CC(C=NN([C@@H]7C(NC(CC7)=O)=O)C8=O)=C8C=C6)CC5)CC4)C=C3)=O)C2(C)C)C=C1Cl
Molecular Formula
C45H51ClN8O5
Molecular Weight
819.39
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
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