S3226
S3226 is an inhibitor for Na+/H+ exchange subtype 3 (NHE3) with an IC50 of 0.2 µmol/L in rat NHE3 transfected fibroblasts. S3226 exhibits protective activity in rat ischemia-induced acute renal failure models[1].
Product Specifications
CAS Number
[215183-03-2]
UNSPSC
12352005
Target
Na+/H+ Exchanger (NHE)
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cardiovascular Disease
Purity
99.65
Smiles
[H]Cl.[H]Cl.C/C(C(NC(N)=N)=O)=C\C(C=CC(C)=C1)=C1/C=C(C)/C(NC(N)=N)=O
Molecular Formula
C17H24Cl2N6O2
Molecular Weight
415.32
References & Citations
[1]Hropot M, et al., S3226, a novel NHE3 inhibitor, attenuates ischemia-induced acute renal failure in rats. Kidney Int. 2001 Dec;60 (6) :2283-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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