Vortioxetine-d3

Vortioxetine-d3 (Lu AA 21004-d3) is a deuterium labeled Vortioxetine (HY-15414) . Vortioxetine (Lu AA 21004) is an antagonist of 5-HT3A and 5-HT7 receptors (Ki: 3.7 nM, 19 nM) and an inhibitor of serotonin transporter (SERT) (Ki: 1.6 nM), as well as a 5-HT1A agonist and a partial agonist of 5-HT1B (Ki: 15 nM, 33 nM) [1][2].

Product Specifications

CAS Number

[1629684-22-5]

Product Name Alternative

Lu AA 21004-d3

UNSPSC

12352005

Target

5-HT Receptor; Isotope-Labeled Compounds; Serotonin Transporter

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease

Smiles

[2H]C([2H])([2H])C1=CC(C)=C(SC2=C(N3CCNCC3)C=CC=C2)C=C1

Molecular Formula

C18H19D3N2S

Molecular Weight

301.46

References & Citations

[1]Bang-Andersen B, et al. Discovery of 1-[2- (2,4-dimethylphenylsulfanyl) phenyl]piperazine (Lu AA21004) : a novel multimodal compound for the treatment of major depressive disorder. J Med Chem. 2011 May 12;54 (9) :3206-21.|[2]Guilloux JP, et al. Antidepressant and anxiolytic potential of the multimodal antidepressant vortioxetine (Lu AA21004) assessed by behavioural and neurogenesis outcomes in mice. Neuropharmacology. 2013 May 28;73C:147-159.