Lesinurad-d4
Lesinurad-d4 (RDEA594-d4) is deuterium labeled Lesinurad. Lesinurad is a URAT1 and OAT inhibitor, is determined to be a substrate for the kidney transporters OAT1 and OAT3 with Km values of 0.85 and 2 μM, respectively.
Product Specifications
CAS Number
[1850305-60-0]
Product Name Alternative
RDEA594-d4
UNSPSC
12352005
Target
Isotope-Labeled Compounds; OAT; URAT1
Related Pathways
Membrane Transporter/Ion Channel; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Smiles
OC(C([2H])([2H])SC1=NN=C(Br)N1C2=CC=C(C3CC3)C4=C2C=C([2H])C([2H])=C4)=O
Molecular Formula
C17H10D4BrN3O2S
Molecular Weight
408.31
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Shen Z, et al. In Vitro and In Vivo Interaction Studies Between Lesinurad, a Selective Urate Reabsorption Inhibitor, and Major Liver or Kidney Transporters. Clin Drug Investig. 2016 Jun;36 (6) :443-52|[3]Sattui SE, et al. Treatment of hyperuricemia in gout: current therapeutic options, latest developments and clinical implications. Ther Adv Musculoskelet Dis. 2016 Aug;8 (4) :145-59.|[4]L.Yeh, et al. RDEA594, a potential uric acid lowering agent througn inhibition of uric acid reuptake , shows better pharmacokinetics rhan its prodrug RDEA806. 2008 ACR/ARHP Annual Scientific Meeting, 24-29 October 2008, USA.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Curated Selection
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