IMA-1
IMA-1 is an inhibitor that inhibits the interaction between arachidonic acid 12-lipoxygenase (ALOX12) and acetyl-CoA carboxylase 1 (ACC1) . IMA-1 significantly blocks the progression of diet-induced non-alcoholic steatohepatitis (NASH) in male mice and crab-eating monkeys, and does not cause hyperlipidemia. IMA-1 can be used for the study of NASH[1].
Product Specifications
CAS Number
[2315406-63-2]
UNSPSC
12352005
Target
Acetyl-CoA Carboxylase; Lipoxygenase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Smiles
O=S(C(C=C1)=CC=C1NCC(C=CC=C2OC)=C2O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)C(O)=O)(NC4=NC5=CC=CC=C5S4)=O
Molecular Formula
C27H27N3O10S2
Molecular Weight
617.65
References & Citations
[1]Zhang XJ, et al. A small molecule targeting ALOX12-ACC1 ameliorates nonalcoholic steatohepatitis in mice and macaques. Sci Transl Med. 2021 Dec 15;13 (624) :eabg8116.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
