MS40
MS40 is a WDR5 PROTAC degrader (Kd = 125 nM) . MS40 promotes the ubiquitination and degradation of WDR5. MS40-induced WDR5 degradation leads to the dissociation of the MLL/KMT2A complex from chromatin, resulting in decreased H3K4me2 levels. MS40 can be used in the study of primary leukemia[1].
Product Specifications
CAS Number
[2407449-49-2]
UNSPSC
12352005
Target
WDR5
Related Pathways
Epigenetics
Field of Research
Cancer
Smiles
O=C1C=C(C(F)(F)F)C(C(NC2=CC(C3=CC(CN4CCN(CC4)CCNC(CCCCCCCNC5=CC=CC(C(N6C7C(NC(CC7)=O)=O)=O)=C5C6=O)=O)=CC=C3)=CC=C2N8CCN(CC8)C)=O)=CN1
Molecular Formula
C52H61F3N10O7
Molecular Weight
995.10
References & Citations
[1]Li D, et al. Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic. Oncogene. 2022 Jun;41 (24) :3328-3340.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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