Cobiprostone

Cobiprostone (SPI 8811) is a type-2 chloride channel activator. Cobiprostone protects against Indomethacin (HY-14397) -induced depolarization of mitochondrial membrane potential and reverses the loss of mitochondrial membrane potential. Cobiprostone protects against NSAID-induced cellular damage[1].

Product Specifications

CAS Number

[333963-42-1]

Product Name Alternative

SPI 8811

UNSPSC

12352005

Hazard Statement

H302-H312-H332

Target

Chloride Channel; Mitochondrial Metabolism

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

O=C(O)CCCCCC[C@H]([C@]1([H])[C@]2([H])O[C@@](O)(C(F)(F)C[C@@H](C)CC)CC1)C(C2)=O

Molecular Formula

C21H34F2O5

Molecular Weight

404.49

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

References & Citations

[1]Cuppoletti J, et al. Cobiprostone Is a Type-2 Chloride Channel Activator That Protects Against NSAID-Induced Cellular Damage: 126. Official journal of the American College of Gastroenterology| ACG, 2007, 102: S163-S164.