Metyltetraprole

Metyltetraprole is a promising fungicide with EC50 values of both 0.002 ppm against sensitive wild-type and G143A mutant of Zymoseptoria tritici. Metyltetraprole is effective against QoI (quinone outside inhibitor) resistant strains. Metyltetraprole inhibits the respiratory chain via complex III[1][2].

Product Specifications

CAS Number

[1472649-01-6]

UNSPSC

12352005

Target

Fungal; Mitochondrial Metabolism

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Concentration

10mM

Purity

99.53

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1N(C)N=NN1C2=CC=CC(C)=C2COC3=NN(C4=CC=C(Cl)C=C4)C=C3

Molecular Formula

C19H17ClN6O2

Molecular Weight

396.83

References & Citations

[1]Matsuzaki Y, et al. Discovery of metyltetraprole: Identification of tetrazolinone pharmacophore to overcome QoI resistance. Bioorg Med Chem. 2020 Jan 1;28 (1) :115211. |[2]Suemoto H, et al. Metyltetraprole, a novel putative complex III inhibitor, targets known QoI-resistant strains of Zymoseptoria tritici and Pyrenophora teres. Pest Manag Sci. 2019 Apr;75 (4) :1181-1189.