PQ-1

PQ-1 is a gap junction enhancer. PQ-1 activates p44/42 MAPK, increases phosphorylated p38-MAPK, reduces Bcl-2 expression, increases the cleavage of pro-caspase-3. PQ-1 affects the Raf-MEK-ERK cascade, induces Apoptosis. PQ-1 can be used in the research of breast cancer[1].

Product Specifications

CAS Number

[955995-48-9]

UNSPSC

12352005

Target

Apoptosis; Bcl-2 Family; Caspase; ERK; MEK; p38 MAPK; Raf

Related Pathways

Apoptosis; MAPK/ERK Pathway; Stem Cell/Wnt

Field of Research

Cancer

Smiles

NCCCNC1=C2C(C(C)=CC=N2)=C(OC3=CC=CC(C(F)(F)F)=C3)C(OC)=C1

Molecular Formula

C21H22F3N3O2

Molecular Weight

405.41

References & Citations

[1]Shishido SN, et al. Induction of Apoptosis by PQ1, a Gap Junction Enhancer that Upregulates Connexin 43 and Activates the MAPK Signaling Pathway in Mammary Carcinoma Cells. Int J Mol Sci. 2016 Jan 29;17 (2) :178.