SYUIQ-5
SYUIQ-5 is a G-quadruplex ligand. SYUIQ-5 stabilizes G-quadruplex and induce senescence. SYUIQ-5 inhibits c-myc gene promoter activity. SYUIQ-5 induces cancer cells autophagy by triggering telomere damage through TRF2 delocalization from telomeres[1].
Product Specifications
CAS Number
[188630-47-9]
UNSPSC
12352005
Hazard Statement
H400
Target
Autophagy; c-Myc; G-quadruplex
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage
Field of Research
Cancer
Purity
98.0
Smiles
CN(C)CCCNC(C1=C(C=CC=C1)N=C23)=C3NC4=C2C=CC=C4
Molecular Formula
C20H22N4
Molecular Weight
318.42
Precautions
H400
References & Citations
[1]Zhou WJ, et al. G-quadruplex ligand SYUIQ-5 induces autophagy by telomere damage and TRF2 delocalization in cancer cells. Mol Cancer Ther. 2009 Dec;8 (12) :3203-13.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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