(9R) -RO7185876
(9R) -RO7185876 (Compound example 16) is a γ-secretase inhibitor. (9R) -RO7185876 inhibits Αβ42 secretion. (9R) -RO7185876 can be used for the researches of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, multi-infarct dementia, dementia pugilistica or Down syndrome[1].
Product Specifications
CAS Number
[2226077-86-5]
UNSPSC
12352005
Target
Amyloid-β; γ-secretase
Related Pathways
Neuronal Signaling; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Purity
99.51
Smiles
FC(C(F)=C(C=C1)F)=C1[C@]2([H])C3=NC(N[C@H]4[C@@H]5CN(C6=NC=NC(C)=C6)C[C@H]4CC5)=NN3CCCC2
Molecular Formula
C25H28F3N7
Molecular Weight
483.53
References & Citations
[1]Bjoern Bartels, et al. Bicyclic heteroaryl derivatives. WO2018083050. WIPO. 2018-05-11.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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