NU 1085
NU 1085 is a potent poly (ADP-ribose) polymerase (PARP) inhibitor with a Ki of 6 nM. NU 1085 shows strong cytotoxicity to cancer cells (LC50 = 83-94 μM) and can enhance the anticancer effect of Temozolomide (HY-17364) . NU 1085 can be used for the research of cancer, such as lung cancer[1].
Product Specifications
CAS Number
[188106-83-4]
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
PARP
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Smiles
NC(C1=C2C(NC(C3=CC=C(O)C=C3)=N2)=CC=C1)=O
Molecular Formula
C14H11N3O2
Molecular Weight
253.26
Precautions
P264-P270-P280-P302+P352-P330-P362+P364-P501
References & Citations
[1]Delaney CA, et al. Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly (adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines. Clin Cancer Res. 2000 Jul;6 (7) :2860-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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