THRX-194556

THRX-194556 is a 5-HT4 receptor agonist. THRX-194556 can be used to study gastrointestinal functional disorders and Alzheimer’s disease[1][2].

Product Specifications

CAS Number

[886579-13-1]

UNSPSC

12352005

Target

5-HT Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Endocrinology; Neurological Disease

Smiles

O=C1C(C(N[C@@H]2C[C@@H](N3C[C@@H](O)CN4CCN(S(C)(=O)=O)CC4)CC[C@@H]3C2)=O)=CC5=CC=CC=C5N1C(C)C

Molecular Formula

C28H41N5O5S

Molecular Weight

559.72

References & Citations

[1]A Multivalent Approach to the Design and Discovery of Orally Efficacious 5-HT4 Receptor Agonists J. Med. Chem., 2009, 52 (17), pp 5330-5343|[2]Long DD, et al. Discovery, oral pharmacokinetics and in vivo efficacy of velusetrag, a highly selective 5-HT (4) receptor agonist that has achieved proof-of-concept in patients with chronic idiopathic constipation. Bioorg Med Chem Lett. 2012 Oct 1;22 (19) :6048-52.|[3]Long DD, Armstrong SR, Beattie DT, Choi SK, Fatheree PR, Gendron RA, Goldblum AA, Humphrey PP, Marquess DG, et al. Discovery, oral pharmacokinetics and in vivo efficacy of a highly selective 5-HT4 receptor agonist: clinical compound TD-2749. Bioorg Med Chem Lett. 2012 Jul 15;22 (14) :4849-53.