(S) -DO271
(S) -DO271 is a non-active control probe targeting ABHD12, and it has almost no inhibitory activity against ABHD12 (IC50 > 100 μM) . (S) -DO271 does not cause the upregulation of inflammatory factors and has no cytotoxicity. (S) -DO271 is suitable as a negative control for validating the functional studies of ABHD12[1].
Product Specifications
CAS Number
[2301865-01-8]
UNSPSC
12352005
Target
MAGL
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Smiles
ClC1=C(N2C[C@H](CCC2)NC(NC3=CN=CC=C3)=S)N=CC=C1OC4=C(C=C(C=C4)OC(F)(F)F)Cl
Molecular Formula
C23H20Cl2F3N5O2S
Molecular Weight
558.40
References & Citations
[1]Ogasawara D, et al. Discovery and Optimization of Selective and in Vivo Active Inhibitors of the Lysophosphatidylserine Lipase α/β-Hydrolase Domain-Containing 12 (ABHD12) . J Med Chem. 2019 Feb 14;62 (3) :1643-1656.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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