Cipamfylline
Cipamfylline is a PDE4 inhibitor that can cause PDE4A4 to accumulate in specific areas of the cell through interaction with the ubiquitin scaffolding protein p62. Cipamfylline can be used in the research of atopic dermatitis[1][2].
Product Specifications
CAS Number
[132210-43-6]
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Smiles
O=C(N1CC2CC2)N(CC3CC3)C4=C(N=C(N)N4)C1=O
Molecular Formula
C13H17N5O2
Molecular Weight
275.31
References & Citations
[1]Griffiths CE, et al. Randomized comparison of the type 4 phosphodiesterase inhibitor cipamfylline cream, cream vehicle and hydrocortisone 17-butyrate cream for the treatment of atopic dermatitis. Br J Dermatol. 2002 Aug;147 (2) :299-307.|[2]Day JP, et al. Elucidation of a structural basis for the inhibitor-driven, p62 (SQSTM1) -dependent intracellular redistribution of cAMP phosphodiesterase-4A4 (PDE4A4) . J Med Chem. 2011 May 12;54 (9) :3331-47.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Curated Selection
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