A-278637

A-278637 is a selective KATP channel opening agent with an EC50 of 102 nM. A-278637 does not interact with other ion channels, including L-type calcium channels or other neurotransmitter receptor systems. A-278637 possesses a greater functional selectivity for urinary bladder versus vascular smooth muscle in vivo. A-278637 can be used for the study of overactive bladder[1][2].

Product Specifications

CAS Number

[227609-66-7]

UNSPSC

12352005

Target

Potassium Channel

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Neurological Disease

Smiles

O=S1(C2=C(CC1)NC(CCCC3=O)=C3[C@]2([H])C4=CC(Br)=C(C=C4)F)=O

Molecular Formula

C17H15BrFNO3S

Molecular Weight

412.27

References & Citations

[1]Fryer RM, et al. (-) - (9S) -9- (3-Bromo-4-fluorophenyl) -2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8 (4H) -one 1,1-dioxide (A-278637), a novel ATP-sensitive potassium channel opener: hemodynamic comparison to ZD-6169, WAY-133537, and nifedipine in the anesthetized canine. J Cardiovasc Pharmacol. 2004 Aug;44 (2) :137-47. |[2]Gopalakrishnan M, et al. (-) - (9S) -9- (3-Bromo-4-fluorophenyl) -2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8 (4H) -one 1,1-dioxide (A-278637) : a novel ATP-sensitive potassium channel opener efficacious in suppressing urinary bladder contractions. I. In vitro characterization. J Pharmacol Exp Ther. 2002 Oct;303 (1) :379-86.