HT1171
HT1171 is a potent and selective inhibitor of mycobacterium tuberculosis proteasome. HT1171 shows strong anti-tuberculosis activity against Mycobacterium tuberculosis H37Rv with an MIC90 of 2 μg/mL and an MIC of 4 μg/mL. When HT1171 concentration is 100 μM, the inhibition rate of human normal hepatocytes L02 is 53.8%. HT1171 can be used in the research of antitubercular agent[1][2].
Product Specifications
CAS Number
[192880-96-9]
UNSPSC
12352005
Hazard Statement
H302
Target
Bacterial; Virus Protease
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
O=C1OC(C2=CC([N+]([O-])=O)=C(C)S2)=NS1
Molecular Formula
C7H4N2O4S2
Molecular Weight
244.25
Precautions
P264-P270-P330-P501
References & Citations
[1]Almeleebia TM, et al. Identification of New Mycobacterium tuberculosis Proteasome Inhibitors Using a Knowledge-Based Computational Screening Approach. Molecules. 2021 Apr 16;26 (8) :2326.|[2]Yang J, et al. 3H-1,2,4-Dithiazol-3-one compounds as novel potential affordable antitubercular agents. Bioorg Med Chem Lett. 2013 Mar 1;23 (5) :1424-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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