3-AP-Me

3-AP-Me is a dimethyl derivative of the nucleotide reductase inhibitor 3-AP (SML0568) . 3-AP-Me can activate the endoplasmic reticulum (ER) stress pathway by promoting the phosphorylation of eIF2α and increasing the gene expression of transcription factors ATF4 and ATF6, leading to cell apoptosis. Additionally, 3-AP-Me can activate the stress kinases c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinases. 3-AP-Me also leads to the upregulation of the spliced mRNA variant XBP1, can be used in cancer research[1].

Product Specifications

CAS Number

[1184391-57-8]

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; Eukaryotic Initiation Factor (eIF) ; JNK; p38 MAPK

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; MAPK/ERK Pathway

Field of Research

Cancer

Smiles

NC1=CC=CN=C1/C=N/NC(N(C)C)=S

Molecular Formula

C9H13N5S

Molecular Weight

223.30

Precautions

P264-P270-P330-P501

References & Citations

[1]Robert Trondl, et al. Triapine and a more potent dimethyl derivative induce endoplasmic reticulum stress in cancer cells. Mol Pharmacol. 2014 Mar;85 (3) :451-9.