MANT-cGMP
MANT-cGMP, a ribose-substituted nucleotide, is an adenylyl cyclase (AC) inhibitor with a Ki of 100 μM and a pKi of 4. MANT-cGMP can be used for the study of heart failure, cancer, and neurological disorders[1].
Product Specifications
CAS Number
[83707-15-7]
UNSPSC
12352005
Target
Adenylate Cyclase
Related Pathways
GPCR/G Protein
Field of Research
Cancer; Neurological Disease; Cardiovascular Disease
Smiles
O=C(C(C=CC=C1)=C1NC)O[C@H]2[C@@](N3C(NC(N)=NC4=O)=C4N=C3)([H])O[C@@](CO5)([H])[C@@]2([H])O[P]5(O)=O
Molecular Formula
C18H19N6O8P
Molecular Weight
478.35
References & Citations
[1]Wang JL, et al. A conformational transition in the adenylyl cyclase catalytic site yields different binding modes for ribosyl-modified and unmodified nucleotide inhibitors. Bioorg Med Chem. 2007 Apr 15;15 (8) :2993-3002.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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