Porfiromycin

Porfiromycin (N-Methylmitomycin C) is a bioreductive alkylating agent that preferentially kill hypoxic tumor cells relative to other aerobic counterparts[1].

Product Specifications

CAS Number

[801-52-5]

Product Name Alternative

N-Methylmitomycin C; NSC-56410; U-14743

UNSPSC

12352005

Target

DNA Alkylator/Crosslinker

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Solubility

10 mM in DMSO

Smiles

CO[C@]12N(C[C@@]3([H])[C@]2([H])N3C)C4=C(C(C(N)=C(C4=O)C)=O)[C@H]1COC(N)=O

Molecular Formula

C16H20N4O5

Molecular Weight

348.35

References & Citations

[1]Keyes SR, Rockwell S, Sartorelli AC. Porfiromycin as a bioreductive alkylating agent with selective toxicity to hypoxic EMT6 tumor cells in vivo and in vitro. Cancer Res. 1985;45 (8) :3642-3645.