BW A4C

BW A4C is a selective 5-lipoxygenase (5-LO) inhibitor. BW A4C is also an inhibitor of linoleic acid 8R-dioxygenase in Gaeumannomyces graminis, with an IC50 value of 0.2 μM. BW A4C can be used in research on diseases such as asthma[1][2].

Product Specifications

CAS Number

[106328-57-8]

UNSPSC

12352005

Target

Lipoxygenase

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

CC(N(O)C/C=C/C1=CC=CC(OC2=CC=CC=C2)=C1)=O

Molecular Formula

C17H17NO3

Molecular Weight

283.32

References & Citations

[1]Payne AN, et al. Hydroxamic acids and hydroxyureas as novel, selective 5-lipoxygenase inhibitors for possible use in asthma. Agents Actions Suppl. 1991;34:189-99.|[2]Brodowsky ID, et al. BW A4C and other hydroxamic acids are potent inhibitors of linoleic acid 8R-dioxygenase of the fungus Gaeumannomyces graminis. Eur J Pharmacol. 1994 Mar 11;254 (1-2) :43-7.