SNJ-1945

SNJ-1945 is an orally active Calpain inhibitor that can cross the blood-brain barrier. SNJ-1945 protects rat hearts against cardiac arrest-reperfusion injury by inhibiting the hydrolysis of α-fodrin. SNJ-1945 inhibits VEGF-induced angiogenesis in retinal endothelial cells. SNJ-1945 also protects SH-SY5Y cells from damage induced by MPP+ (HY-W008719) and Rotenone (HY-B1756) . SNJ-1945 exhibits anti-inflammatory and neuroprotective activities in a mouse model of multiple sclerosis. SNJ-1945 can be used for the research of cardiovascular, nervous system and inflammatory diseases[1][2][3][4].

Product Specifications

CAS Number

[854402-59-8]

UNSPSC

12352005

Target

Calcium Channel; Proteasome; Reactive Oxygen Species (ROS)

Related Pathways

Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

Field of Research

Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Smiles

O=C(C(NC1CC1)=O)[C@@H](NC([C@H](CC(C)C)NC(OCCOCCOC)=O)=O)CC2=CC=CC=C2

Molecular Formula

C25H37N3O7

Molecular Weight

491.58

References & Citations

[1]Yoshikawa Y, et al. Cardioprotective effects of a novel calpain inhibitor SNJ-1945 for reperfusion injury after cardioplegic cardiac arrest. Am J Physiol Heart Circ Physiol. 2010 Feb;298 (2) :H643-51.|[2]Ma H, et al. Calpain inhibitor SNJ-1945 attenuates events prior to angiogenesis in cultured human retinal endothelial cells. J Ocul Pharmacol Ther. 2009 Oct;25 (5) :409-14.|[3]Knaryan VH, et al. SNJ-1945, a calpain inhibitor, protects SH-SY5Y cells against MPP (+) and rotenone. J Neurochem. 2014 Jul;130 (2) :280-90.|[4]Trager N, et al. Effects of a novel orally administered calpain inhibitor SNJ-1945 on immunomodulation and neurodegeneration in a murine model of multiple sclerosis. J Neurochem. 2014 Jul;130 (2) :268-79.