LY-300168

LY 300168 (GYKI 53655) is a non-competitive, blood-brain-barrier permeable AMPA receptor antagonist. LY 300168 attenuates hippocampal injury. LY 300168 blocks the sound-induced clonic and tonic convulsions[1][2].

Product Specifications

CAS Number

[143692-18-6]

Product Name Alternative

GYKI 53655

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

IGluR

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

O=C(N1N=C(C2=CC=C(N)C=C2)C3=CC(OCO4)=C4C=C3CC1C)NC

Molecular Formula

C19H20N4O3

Molecular Weight

352.39

Precautions

P261-P280-P302+P352

References & Citations

[1]Liu XH, et al. The non-competitive AMPA antagonist LY 300168 (GYKI 53655) attenuates AMPA-induced hippocampal injury in neonatal rodents. Neurosci Lett. 1997 Oct 10;235 (1-2) :93-7. |[2]Szabados T, et al. Comparison of anticonvulsive and acute neuroprotective activity of three 2,3-benzodiazepine compounds, GYKI 52466, GYKI 53405, and GYKI 53655. Brain Res Bull. 2001 Jun;55 (3) :387-91.