Tetrazine-biotin
Tetrazine-biotin is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Tetrazine-biotin is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
Product Specifications
CAS Number
[1714123-51-9]
UNSPSC
12352203
Hazard Statement
H315, H319
Target
ADC Linker
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
98
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(NCC1=CC=C(C2=NN=CN=N2)C=C1)CCCC[C@@H]3SC[C@]([C@]3([H])N4)([H])NC4=O
Molecular Formula
C19H23N7O2S
Molecular Weight
413.50
Precautions
H315, H319
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker
Available Sizes
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