Ascofuranone

Ascofuranone, a prenylphenol antibiotic, is a potent and selective trypanosome alternative oxidase (TAO) inhibitor. Ascofuranone has inhibitory activity against human dihydroorotate dehydrogenase (DHODH) . Ascofuranone has diverse physiological activities, including antibiotic, hypolipidemic, anti-inflammatory, and anti-cancer[1][2].

Product Specifications

CAS Number

[38462-04-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; Dihydroorotate Dehydrogenase; DNA/RNA Synthesis; Parasite

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Field of Research

Cancer; Infection; Inflammation/Immunology; Cardiovascular Disease

Purity

Smiles

C/C([C@@H]1CC(C(C)(O1)C)=O)=C\CC/C(C)=C/CC2=C(C(C=O)=C(C(Cl)=C2O)C)O

Molecular Formula

C23H29ClO5

Molecular Weight

420.93

Precautions

H302, H315, H319, H335

References & Citations

[1]Fukai Y, et al. Functional expression of the ascofuranone-sensitive Trypanosoma brucei brucei alternative oxidase in the cytoplasmic membrane of Escherichia coli. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1999 Oct;124 (2) :141-8. |[2]Araki Y, et al. Heterologous production of ascofuranone and ilicicolin A in Aspergillus sojae. J Gen Appl Microbiol. 2022 Jun 20;68 (1) :10-16.