(2R) -RXP470.1

(2R) -RXP470.1 ((2R) -RXP-470) is the (2R) -isomer of RXP470.1 (HY-135517) . RXP470.1 (RXP-470) is a potent, selective MMP-12 inhibitor with a Ki of 0.2 nM against human MMP-12[1].

Product Specifications

Product Name Alternative

(2R) -RXP-470

UNSPSC

12352101

Target

MMP

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cardiovascular Disease

Purity

98.70

Smiles

O=P(O)(C1=CC=C(Br)C=C1)C[C@H](C(N[C@H](CCC(O)=O)C(N[C@H](C(N)=O)CCC(O)=O)=O)=O)CC2=CC(C3=CC=C(C4=CC(Cl)=CC=C4)C=C3)=NO2

Molecular Formula

C35H35BrClN4O10P

Molecular Weight

818.00

References & Citations

[1]Jason L Johnson, et al. A selective matrix metalloproteinase-12 inhibitor retards atherosclerotic plaque development in apolipoprotein E-knockout mice. Arterioscler Thromb Vasc Biol. 2011 Mar;31 (3) :528-35.