PF-06422913
PF-06422913 is an orally active, potent and selective metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator[1].
Product Specifications
CAS Number
[1539296-46-2]
UNSPSC
12352005
Target
MGluR
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Inflammation/Immunology
Smiles
FC(F)(C1=C(C2=NN(C)C3=C2N=CC(OCC4=NC=CC=C4)=N3)C=NC=C1)F
Molecular Formula
C18H13F3N6O
Molecular Weight
386.33
References & Citations
[1]Falgun Shah, et al. Mechanisms of Skin Toxicity Associated with Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators. Cell Chem Biol. 2017 Jul 20;24 (7) :858-869.e5.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR5
Curated Selection
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