25I-NBF (hydrochloride)

25I-NBF hydrochloride is a highly potent partial agonist for the 5-HT2A receptors receptor with a Ki value of 0.26 nM and an EC50 value of 1.6 nM[1].

Product Specifications

CAS Number

[1539266-13-1]

UNSPSC

12352005

Hazard Statement

H225-H301+H311+H331-H370

Target

5-HT Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

COC1=C(I)C=C(OC)C(CCNCC2=CC=CC=C2F)=C1.[H]Cl

Molecular Formula

C17H20ClFINO2

Molecular Weight

451.70

Precautions

P210-P233-P240-P241-P242-P243-P260-P261-P264-P270-P271-P280-P302+P352-P303+P361+P353-P304+P340-P308+P311-P330-P361+P364-P370+P378-P403+P233-P403+P235-P405-P501

References & Citations

[1]Braden MR, et al. Molecular interaction of serotonin 5-HT2A receptor residues Phe339 (6.51) and Phe340 (6.52) with superpotent N-benzyl phenethylamine agonists. Mol Pharmacol. 2006 Dec;70 (6) :1956-64.