TFCA
TFCA is a liver X receptor α (LXRα) antagonist. TFCA inhibits ligand-activated LXRα coactivation and transcriptional expression of the downstream target genes involved in fatty acid synthesis. TFCA attenuates ligand-induced lipogenesis and fatty liver by selectively inhibiting LXRα in the liver[1].
Product Specifications
CAS Number
[895700-18-2]
UNSPSC
12352005
Hazard Statement
H302
Target
LXR
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Metabolic Disease
Smiles
O=C(NC1=CC=C(C(F)(F)F)C=C1)/C=C/C2=CC=C(OC)C(OC)=C2
Molecular Formula
C18H16F3NO3
Molecular Weight
351.32
Precautions
P264-P270-P330-P501
References & Citations
[1]Sim WC, et al. Cinnamamides, Novel Liver X Receptor Antagonists that Inhibit Ligand-Induced Lipogenesis and Fatty Liver. J Pharmacol Exp Ther. 2015 Dec;355 (3) :362-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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