SBI-0087702
SBI-0087702 promots the cytoplasmic localization of ATF2 in melanoma cells. SBI-0087702-induced translocation of ATF2 to the mitochondria results in increased apoptosis due to loss of mitochondrial membrane integrity. SBI-0087702 also inhibits growth and motility of melanoma cells. SBI-0087702 was shown to inhibit ATF2 phosphorylation on Thr52 by PKCε[1].
Product Specifications
CAS Number
[864431-36-7]
UNSPSC
12352005
Hazard Statement
H318, H410
Target
PKC
Related Pathways
Epigenetics; TGF-beta/Smad
Field of Research
Cancer
Purity
99.55
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
COC1=CC=C(CCNCC2=C3C=CC=CC3=C(OC)C=C2)C=C1
Molecular Formula
C21H23NO2
Molecular Weight
321.41
Precautions
H318, H410
References & Citations
[1]Tal Varsano, et al. Inhibition of Melanoma Growth by Small Molecules that Promote the Mitochondrial Localization of ATF2. Clin Cancer Res. 2013 May 15;19 (10) :2710-22.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
