8-Nitro-cGMP

8-Nitro-cGMP is an electrophilic second messenger of redox signaling that can form a protein-S-cGMP adduct in s-guanylation process. 8-Nitro-cGMP is an autophagy inducer. 8-Nitro-cGMP promotes RANKL-induced osteoclast differentiation from macrophages. 8-Nitro-cGMP has vasodilator effect, and ameliorates the vascular endothelial dysfunction in diabetic mice[1][2][3][4].

Product Specifications

CAS Number

[913645-39-3]

UNSPSC

12352005

Target

Autophagy; Endogenous Metabolite; Nucleoside Antimetabolite/Analog

Related Pathways

Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Field of Research

Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease

Smiles

O=C1C2=C(N([C@@H]3O[C@H](CO4)[C@@H](OP4(O)=O)[C@H]3O)C([N+]([O-])=O)=N2)NC(N)=N1

Molecular Formula

C10H11N6O9P

Molecular Weight

390.20

References & Citations

[1]Ihara H, et al. Exposure to Electrophiles Impairs Reactive Persulfide-Dependent Redox Signaling in Neuronal Cells. Chem Res Toxicol. 2017 Sep 18;30 (9) :1673-1684. |[2]Tokutomi Y, et al. Vascular responses to 8-nitro-cyclic GMP in non-diabetic and diabetic mice. Br J Pharmacol. 2011 Apr;162 (8) :1884-93. |[3]Kaneko K, et al. 8-Nitro-cGMP is a promoter of osteoclast differentiation induced by RANKL. Nitric Oxide. 2018 Jan 30;72:46-51.|[4]Rawet-Slobodkin M, Elazar Z. 8-nitro-cGMP--a new player in antibacterial autophagy. Mol Cell. 2013 Dec 26;52 (6) :767-8.