5-O-Desmethyl donepezil

5-O-Desmethyl donepezil is a metabolite of Donepezil (HY-14566) . 5-O-Desmethyl donepezil is an inhibitor for hERG channel with an IC50 of 1.5 μM[1].

Product Specifications

CAS Number

[120013-57-2]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Drug Metabolite; Potassium Channel

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology

Smiles

O=C1C(CC2CCN(CC3=CC=CC=C3)CC2)CC4=C1C=C(OC)C(O)=C4

Molecular Formula

C23H27NO3

Molecular Weight

365.47

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Chae YJ, et al. Effects of donepezil on hERG potassium channels. Brain Res. 2015 Feb 9;1597:77-85.

Shipping Conditions

Room temperature

Scientific Category

Reference compound2

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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