5-O-Desmethyl donepezil
5-O-Desmethyl donepezil is a metabolite of Donepezil (HY-14566) . 5-O-Desmethyl donepezil is an inhibitor for hERG channel with an IC50 of 1.5 μM[1].
Product Specifications
CAS Number
[120013-57-2]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Drug Metabolite; Potassium Channel
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Smiles
O=C1C(CC2CCN(CC3=CC=CC=C3)CC2)CC4=C1C=C(OC)C(O)=C4
Molecular Formula
C23H27NO3
Molecular Weight
365.47
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Chae YJ, et al. Effects of donepezil on hERG potassium channels. Brain Res. 2015 Feb 9;1597:77-85.
Shipping Conditions
Room temperature
Scientific Category
Reference compound2
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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