MI-888

MI-888 is an orally active MDM2 inhibitor with a Ki of 0.44 nM. MI-888 can inhibit the MDM2-p53 interaction. MI-888 has favorable pharmacokinetic properties and anti-tumor activity[1].

Product Specifications

CAS Number

[1303607-59-1]

UNSPSC

12352005

Target

MDM-2/p53

Related Pathways

Apoptosis

Field of Research

Cancer

Smiles

CC(C)(C)C[C@H]1[C@]2(C3=CC=C(Cl)C=C3NC2=O)[C@@H](C4=C(C(Cl)=CC=C4)F)[C@@H](N1)C(N[C@H]5C[C@@](O)(C5)C)=O

Molecular Formula

C28H32Cl2FN3O3

Molecular Weight

548.48

References & Citations

[1]Zhao Y, et al. A potent small-molecule inhibitor of the MDM2-p53 interaction (MI-888) achieved complete and durable tumor regression in mice. J Med Chem. 2013 Jul 11;56 (13) :5553-61.