Niravoline
Niravoline (RU51599) is an arginine vasopressin (AVP) release inhibitor and a selective kappa opioid receptor agonist. Niravoline has a pure water diuresis effect without associated electrolyte excretion. Niravoline can reduce brain oedema following transient forebrain ischaemia in rats[1].
Product Specifications
CAS Number
[130610-93-4]
Product Name Alternative
RU51599
UNSPSC
12352005
Target
Opioid Receptor; Vasopressin Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(N([C@@H]1[C@@H](N2CCCC2)CC3=C1C=CC=C3)C)CC4=CC=CC([N+]([O-])=O)=C4
Molecular Formula
C22H25N3O3
Molecular Weight
379.45
References & Citations
[1]Ikeda Y, et al. Arginine vasopressin release inhibitor RU51599 attenuates brain oedema following transient forebrain ischaemia in rats. Acta Neurochir (Wien) . 1997;139 (12) :1166-71; discussion 1171-2.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
κ Opioid Receptor/KOR
Curated Selection
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