CHIKV-IN-1

CHIKV-IN-1 (Compound 3a) is a compound that inhibits the Chikungunya virus (CHIKV) with an EC50 of 0.12 μM. CHIKV-IN-1 is a potent inhibitor of the S-adenosyl-L-homocysteine hydrolase (SAH hydrolase), with an IC50 of 0.36 μM. CHIKV-IN-1 is only effective against CHIKV and some other alphaviruses, but has no activity against other RNA viruses such as SARS-CoV, MERS-CoV, and ZIKV. CHIKV-IN-1 has extremely low cytotoxicity (CC₅₀ > 250 μM), and it has an extremely high selectivity index (SI > 2083) . CHIKV-IN-1 can be used in research on anti-Chikungunya virus[1].

Product Specifications

CAS Number

[2236598-97-1]

UNSPSC

12352005

Target

CHIKV; Nucleoside Antimetabolite/Analog

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Field of Research

Infection

Smiles

F[C@H]1[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@@H]([C@@H]([C@H]1CCO)O)O

Molecular Formula

C12H16FN5O3

Molecular Weight

297.29

References & Citations

[1]Shin YS, et al. Identification of 6'-β-fluoro-homoaristeromycin as a potent inhibitor of chikungunya virus replication. Eur J Med Chem. 2020 Feb 1;187:111956.