Aminoflavone

Aminoflavone is an anti-tumor agent. Aminoflavone inhibits the expression of ITGA6/SOX2 by activating the AhR-miR-125b-2-3p axis, thereby targeting breast cancer stem cells. Aminoflavone induces an increase in intracellular ROS, increases the level of oxidative DNA damage marker 8-oxodG and DNA-protein cross-links. Aminoflavone causes S-phase arrest, activates caspase-3/8/9 and induces apoptosis (apoptosis) . Aminoflavone inhibits HIF-1α expression in a manner independent of AhR. Aminoflavone can be used for the study of breast cancer[1][2][3].

Product Specifications

CAS Number

[165179-35-1]

Product Name Alternative

NSC-686288

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

Apoptosis; Aryl Hydrocarbon Receptor; Caspase; DNA Alkylator/Crosslinker; DNA/RNA Synthesis; HIF/HIF Prolyl-Hydroxylase; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Cancer

Smiles

O=C1C=C(C2=CC=C(N)C(F)=C2)OC3=C(F)C(C)=C(F)C(N)=C13

Molecular Formula

C16H11F3N2O2

Molecular Weight

320.27

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

References & Citations

[1]Terzuoli E, et al. Aminoflavone, a ligand of the aryl hydrocarbon receptor, inhibits HIF-1alpha expression in an AhR-independent fashion. Cancer Res. 2010 Sep 1;70 (17) :6837-48.|[2]McLean L, et al. Aminoflavone induces oxidative DNA damage and reactive oxidative species-mediated apoptosis in breast cancer cells. Int J Cancer. 2008 Apr 1;122 (7) :1665-74.|[3]Mavingire N, et al. Aminoflavone upregulates putative tumor suppressor miR-125b-2-3p to inhibit luminal A breast cancer stem cell-like properties. Precis Clin Med. 2022 Mar 28;5 (2) :pbac008.