(±) -E-Homocamptothecin

(±) -E-Homocamptothecin (BN 80245) is a topoisomerase I inhibitor. (±) -E-Homocamptothecin can be used for the research of cancer[1].

Product Specifications

CAS Number

[186668-40-6]

Product Name Alternative

BN 80245

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Topoisomerase

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C1OCC2=C(C(C1)(CC)O)C=C(C3=C(C4)C=C5C=CC=CC5=N3)N4C2=O

Molecular Formula

C21H18N2O4

Molecular Weight

362.38

Precautions

P261-P280-P302+P352

References & Citations

[1]Lavergne O, et al. BN 80245: an E-ring modified camptothecin with potent antiproliferative and topoisomerase I inhibitory activities[J]. Bioorganic & Medicinal Chemistry Letters, 1997, 7 (17) : 2235-2238.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Topo I

Curated Selection

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