IRucaparib-TP3
IRucaparib-TP3 is a selective PARP1 degrader (DC50=36 nM) . iRucaparib-TP3 is promising for research of oncology (e.g., BRCA-mutated cancers) and neurodegenerative diseases[1].
Product Specifications
CAS Number
[2410557-01-4]
UNSPSC
12352005
Target
PARP
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer; Neurological Disease
Solubility
10 mM in DMSO
Smiles
O=C1NCCC2=C(C3=CC=C(CN(C)CCCCC4=CN(CCOCCOCCOCCNC5=C6C(C(N(C7C(NC(CC7)=O)=O)C6=O)=O)=CC=C5)N=N4)C=C3)NC8=CC(F)=CC1=C82
Molecular Formula
C46H52FN9O8
Molecular Weight
877.96
References & Citations
[1]Wang S, et al. Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation. Nat Chem Biol. 2019 Dec;15 (12) :1223-1231.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP1
Curated Selection
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