SB-773812

SB-773812 is a moderate-affinity antagonist at dopamine receptor 2 (pKi=7.4) and a high-affinity antagonist at the dopamine receptor 3 (pKi=8.5) and at the serotonin 5-hydroxytryptamine receptors 2A (pKi=9.0), 2C (pKi=8.1), and 6 (pKi=8.1) . SB-773812 is promising for research of central nervous system disorders[1][2].

Product Specifications

CAS Number

[630407-66-8]

UNSPSC

12352005

Target

5-HT Receptor; Dopamine Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

CN1CCC2=CC(OC)=C(S(=O)(C3=CC=C(OCC4=CC=C(Cl)C=C4)C=C3)=O)C=C2CC1

Molecular Formula

C25H26ClNO4S

Molecular Weight

472.00

References & Citations

[1]Garg A, et al. Amit Garg A Mechanism Based Population Pharmacokinetic-Pharmacodynamic Model for Epoetin Alfa and Darbepoetin Alfa in Chronic Kidney Disease Patients[J]. Poster Abstracts PAGE 2010, 47.|[2]Catafau AM, et al. Contribution of SPECT measurements of D2 and 5-HT2A occupancy to the clinical development of the antipsychotic SB-773812. J Nucl Med. 2011 Apr;52 (4) :526-34.