5-Methyl cromolyn (disodium)

5-Methyl cromolyn (C5OH) disodium, an analog of Cromolyn (HY-B1619), is a S100P inhibitor. 5-Methyl cromolyn disodium inhibits the binding of S100P to its receptor RAGE, NF-κB activity and cell proliferation, and promotes Gemcitabine (HY-17026) -induced apoptosis. 5-Methyl cromolyn disodium reduces tumor growth and metastasis, and prolongs survival in mouse models of syngeneic PDAC. 5-Methyl cromolyn disodium can be used for pancreatic cancer like pancreatic ductal adenocarcinoma (PDAC) research[1].

Product Specifications

CAS Number

[1221154-42-2]

Product Name Alternative

C5OH

UNSPSC

12352005

Target

Apoptosis; Drug Derivative; NF-κB

Related Pathways

Apoptosis; NF-κB; Others

Field of Research

Cancer

Smiles

O=C(C(OC1=CC=CC(OCCC(CCOC(C=CC=C2OC(C(O[Na])=O)=C3)=C2C3=O)O)=C14)=CC4=O)O[Na]

Molecular Formula

C25H18Na2O11

Molecular Weight

540.38

References & Citations

[1]Arumugam T, et al. Designing and developing S100P inhibitor 5-methyl cromolyn for pancreatic cancer therapy. Mol Cancer Ther. 2013 May;12 (5) :654-62.