NIM258

NIM258 is a potent nonimmunosuppressive cyclophilin inhibitor (cyclophilin A Kd = 1.2 nM) with anti-HCV activity (EC50 = 40 nM) . NIM258 can be used for HCV infection research[1].

Product Specifications

CAS Number

[1589093-01-5]

UNSPSC

12352005

Target

Cyclophilin; HCV

Related Pathways

Anti-infection; Immunology/Inflammation

Applications

COVID-19-anti-virus

Field of Research

Infection

Smiles

COCCN(CC1)CCN1C[C@H]([C@@](N2C)([H])C(N[C@H](C(N([C@H](C(N[C@H](C(N[C@@H](C(N([C@H](C(N(C)[C@@H](CC(C)C)C(N(C)[C@H](C(C)C)C(N(C)[C@]([C@H](O)[C@H](C)C/C=C/C)([H])C(N[C@](CC)([H])C(N(C)[C@H](C)C2=O)=O)=O)=O)=O)=O)CC(C)C)C)=O)C)=O)C)=O)CC(C)C)C)=O)C(C)C)=O)C

Molecular Formula

C69H125N13O13

Molecular Weight

1344.81

References & Citations

[1]Fu J, et al. Potent nonimmunosuppressive cyclophilin inhibitors with improved pharmaceutical properties and decreased transporter inhibition. J Med Chem. 2014 Oct 23;57 (20) :8503-16.