Colterol

Colterol is the agonist for adrenergic receptor, and exhibits good affinity to β1-adrenoreceptor (heart) and β2-adrenoreceptor (lung) with IC50 of 645 nM and 147 nM. Colterol exhibits potential as a bronchodilator[1][2].

Product Specifications

CAS Number

[18866-78-9]

UNSPSC

12352005

Hazard Statement

H302-H312-H332

Target

Adrenergic Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Cardiovascular Disease

Smiles

OC1=CC=C(C(O)CNC(C)(C)C)C=C1O

Molecular Formula

C12H19NO3

Molecular Weight

225.28

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

References & Citations

[1]Kusayama T, et al., Binding of a catechol derivative of denopamine (T-0509) and N-tert-butylnoradrenaline (Colterol) to beta 1- and beta 2-adrenoceptors. Biol Pharm Bull. 1994 Aug;17 (8) :1023-7. |[2]Walker SB, et al., Bitolterol mesylate: a beta-adrenergic agent. Chemistry, pharmacokinetics, pharmacodynamics, adverse effects and clinical efficacy in asthma. Pharmacotherapy. 1985 May-Jun;5 (3) :127-37.