AZ1136

AZ1136 is a highly selective γ-secretase modulator (GSM) . AZ1136 reduces the levels of Aβ42 and Aβ40, with its IC50 being 990 and 1400 nM. AZ1136 increases the levels of Aβ39 and Aβ37, but does not affect Aβ38. AZ1136 can be used for the study of Alzheimer's disease[1].

Product Specifications

CAS Number

[1380508-60-0]

UNSPSC

12352005

Target

Amyloid-β; γ-secretase

Related Pathways

Neuronal Signaling; Stem Cell/Wnt

Field of Research

Neurological Disease

Smiles

O=C1C2=CN=C(OC3=CC=C(C4=CN=CO4)C=C3)N=C2N(C)CC(C5=CC=CC=C5)N1C

Molecular Formula

C24H21N5O3

Molecular Weight

427.46

References & Citations

[1]Borgegard T, et al. First and second generation γ-secretase modulators (GSMs) modulate amyloid-β (Aβ) peptide production through different mechanisms. J Biol Chem. 2012 Apr 6;287 (15) :11810-9.