BAY-866
BAY-866, a sulfamide campound, is an allosteric MEK1 inhibitor with an IC50 of 14 nM. BAY-866 inhibits cell growth of A375 (BRAF) and HCT116 (K-Ras) with IC50s of 13 nM and 277 nM, respectively. BAY-866 inhibits tumor growth in K-Ras-mutated A549 xenograft model[1].
Product Specifications
CAS Number
[1836185-18-2]
UNSPSC
12352005
Target
MEK
Related Pathways
MAPK/ERK Pathway
Field of Research
Cancer
Smiles
O=C(C1=C(C=C(C(F)=C1NC2=CC=C(C=C2F)I)F)OC3=CC=C(C(NS(=O)(N)=O)=C3)F)N
Molecular Formula
C19H13F4IN4O4S
Molecular Weight
596.29
References & Citations
[1]Hartung IV, et al. Optimization of allosteric MEK inhibitors. Part 2: Taming the sulfamide group balances compound distribution properties. Bioorg Med Chem Lett. 2016 Jan 1;26 (1) :186-93.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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